Scientific Publications

ALGISYL®:

Anker SD et al. A prospective comparison of alginate-hydrogel with standard medical therapy to determine impact on functional capacity and clinical outcomes in patients with advanced heart failure (AUGMENT-HF trial). Eur Heart J. 2015 Sep 7;36(34):2297-309. doi: 10.1093/eurheartj/ehv259. Epub 2015 Jun 16.

Lee RJ et al. The feasibility and safety of Algisyl-LVR™ as a method of left ventricular augmentation in patients with dilated cardiomyopathy: Initial first in man clinical results. Int J Cardiol. 2015 Nov 15;199:18-24. doi: 10.1016/j.ijcard.2015.06.111. Epub 2015 Jul 2.

DL Mann et al. Efficacy of Left Ventricular Augmentation With Algisyl-LVR in the Treatment of Advanced Heart Failure Patients With Ischemic and Non-Ischemic Cardiomyopathy: Results of the AUGMENT-HF Multicenter Randomized Controlled Trial. Presentation at the American Heart Association 2014 Scientific Sessions (Chicago, IL, November 2014). Circulation 2014: 130(23): 2105-26. doi: 10.1161/01.cir.0000457464.79076.2c

DL Mann et al. A Multicenter, Randomized Study Assessing the Efficacy of Left Ventricular Augmentation with Algisyl-LVR in the Treatment of Advanced Heart Failure Patients with Ischemic and Non-ischemic Cardiomyopathy: Interim Results of the AUGMENT-HF Study. Presentation at the American Heart Association 2013 Scientific Sessions (Dallas, TX, November 2013). my.americanheart.org/idc/groups/ahamah-public/.../ucm_458316.pdf

LC Lee et al. Algisyl-LVR™ with coronary artery bypass grafting reduces left ventricular wall stress and improves function in the failing human heart. Int J Cardiol. 2013 Oct 3;168(3):2022-8

Sabbah HN et al. Augmentation of Left Ventricular Wall Thickness With Alginate Hydrogel Implants Improves Left Ventricular Function and Prevents Progressive Remodeling in Dogs With Chronic Heart Failure. JCHF. 2013;1(3):252-258. doi:10.1016/j.jchf.2013.02.006

LC Lee et al. Reduction in left ventricular wall stress and improvement in function in failing hearts using Algisyl-LVR. J Vis Exp. 2013 Apr 8; (74).

RJ Lee et al. Polymer-based restoration of left ventricular mechanics. Cell Transplant. 2013;22(3):529-33. doi: 10.3727/096368911X637461. Epub 2012 Mar 28.

PRE-CLINICAL RESEARCH PROGRAMS:

Xin M, Olson EN, Bassel-Duby R. Mending broken hearts: cardiac development as a basis for adult heart regeneration and repair. Nature Reviews Molecular Cell Biology, 14(8):529-41. doi: 10.1038/nrm3619. Epub 2013 Jul 10.

Russell JL, Goetsch SC, Aguilar HR, Frantz DE, Schneider JW. Targeting native adult heart progenitors with cardiogenic small molecules. ACS Chem Biol. 2012 Jun 15;7(6):1067-76. doi: 10.1021/cb200525q.

Dioum EM, Osborne JK, Goetsch S, Russell J, Schneider JW, Cobb MH. A small molecule differentiation inducer increases insulin production by pancreatic β cells. Proc Natl Acad Sci U S A. 2011 Dec 20;108(51):20713-8. doi: 10.1073/pnas.1118526109. Epub 2011 Dec 5.

Velasquez LS, Sutherland LB, Liu Z, Grinnell F, Kamm KE, Schneider JW, Olson EN, Small EM. Activation of MRTF-A-dependent gene expression with a small molecule promotes myofibroblast differentiation and wound healing. Proc Natl Acad Sci U S A. 2013 Oct 15;110(42):16850-5. doi: 10.1073/pnas.1316764110. Epub 2013 Sep 30.

Song K, Nam YJ, Luo X, Qi X, Tan W, Huang GN, Acharya A, Smith CL, Tallquist MD, Neilson EG, Hill JA, Bassel-Duby R, Olson EN. Heart repair by reprogramming non-myocytes with cardiac transcription factors. Nature, 485(7400):599-604.